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Model Behavior

Animal Experiments, Complexity, and the Genetics of Psychiatric Disorders

Model Behavior

Animal Experiments, Complexity, and the Genetics of Psychiatric Disorders

Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field.

Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.

272 pages | 3 halftones, 3 line drawings, 1 table | 6 x 9 | © 2018

Biological Sciences: Behavioral Biology

History of Science

Medicine

Psychology: Animal Behavior

Sociology: Theory and Sociology of Knowledge

Reviews

“Scientists are accustomed to investigating the natural world and to drawing conclusions about it. In Model Behavior, historian of science Nicole Nelson turns the spotlight on them for a change. Like an anthropologist facing a new tribe, Nelson focuses her keen analytical mind on a US team researching the genetics of alcoholism in mice. The result is a stimulating and challenging exploration of science, and of how social scientists think about science. Everybody wins.”

New Scientist

“Overall, the book is a first-class piece of scholarship: the arguments are clearly made, stimulating and well-supported. It contributes significantly to continued interest in the centrality of model organisms to the socio-epistemic character of the modern biosciences. . . . It will interest those working on all aspects of social genomics, those who study laboratory animal research and modelling and, because of its re-entry into the constructionist heartland of STS itself, a wide range of scholars concerned with the development of the discipline more widely.”

New Genetics and Society

“In this excellent book, a compelling read for STS scholars interested in the way in which biomedical knowledge of psychiatric conditions is produced, Nelson takes us to the oft-hidden world of the animal house. . . . This is an extremely well-crafted and engaging book illustrating how, in order to produce ‘enduring genetic findings,’ researchers need to negotiate the relationship between humans and animals; between an isolated, local experiment and what forms part of a more general model; and between a behavioural trait and an experimental artefact. It is a must read for those interested in the role laboratory animals and their handlers play in the construction of biomedical knowledge, questioning the possibilities of engaging with ideas of complexity when ultimately modelling is a form of simplification.”

Sociology of Health & Illness

Table of Contents

Introduction: A Furry, One-Ounce Human?
1 Containing Complexities in the Animal Behavior Genetics Laboratory
2 Animal Behavior Genetics, the Past and the Future
3 Building Epistemic Scaffolds for Modeling Work
4 Epistemic By-Products: Learning about Environments while Studying Genetics
5 Understanding Binge Drinking
6 Leaving the Laboratory
Conclusion: An Expanded Vocabulary for the Laboratory
Acknowledgments
Appendix
Notes
Bibliography

Awards

International Society for the History of Behavioral and Social Sciences: Cheiron Book Prize
Finalist

Forum for the History of Science in America: Philip J. Pauly Book Prize
Short Listed

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