Cloth $25.00 ISBN: 9780226654805 Published October 2019 Not for sale in Europe or the British Commonwealth except Canada
E-book $18.00 About E-books ISBN: 9780226676173 Published October 2019 Not for sale in Europe or the British Commonwealth except Canada Also Available From
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How to Grow a Human

Adventures in How We Are Made and Who We Are

Philip Ball

How to Grow a Human

Philip Ball

272 pages | 30 halftones | 6 x 9 | © 2019
Cloth $25.00 ISBN: 9780226654805 Published October 2019 Not for sale in Europe or the British Commonwealth except Canada
E-book $18.00 About E-books ISBN: 9780226676173 Published October 2019 Not for sale in Europe or the British Commonwealth except Canada
Two summers ago, scientists removed a tiny piece of flesh from Philip Ball’s arm and turned it into a rudimentary “mini-brain.” The skin cells, removed from his body, did not die but were instead transformed into nerve cells that independently arranged themselves into a dense network and communicated with each other, exchanging the raw signals of thought. This was life—but whose? 

In his most mind-bending book yet, Ball makes that disconcerting question the focus of a tour through what scientists can now do in cell biology and tissue culture. He shows how these technologies could lead to tailor-made replacement organs for when ours fail, to new medical advances for repairing damage and assisting conception, and to new ways of “growing a human.” For example, it might prove possible to turn skin cells not into neurons but into eggs and sperm, or even to turn oneself into the constituent cells of embryos. Such methods would also create new options for gene editing, with all the attendant moral dilemmas. Ball argues that such advances can therefore never be about “just the science,” because they come already surrounded by a host of social narratives, preconceptions, and prejudices. But beyond even that, these developments raise questions about identity and self, birth and death, and force us to ask how mutable the human body really is—and what forms it might take in years to come. 
 
Contents
PROLOGUE

INTRODUCTION
My Brain in a Dish

CHAPTER 1
Pieces of Life: Cells past and present

CHAPTER 2
Body Building: Growing humans the old-fashioned way

FIRST INTERLUDE
The Human Superorganism: How cells became communities

CHAPTER 3
Immortal Flesh: How tissues were grown outside the body

SECOND INTERLUDE
Heroes and Villains: Cancer, immunity and our cellular ecosystem

CHAPTER 4
Twists of Fate: How to reprogramme a cell

CHAPTER 5
The Spare Parts Factory: Making tissues and organs from reprogrammed cells

CHAPTER 6
Flesh of My Flesh: Questioning the future of sex and reproduction

CHAPTER 7
Hideous Progeny? The futures of growing humans

THIRD INTERLUDE
Philosophy of the Lonely Mind: Can a brain exist in a dish?

CHAPTER 8
Return of the Meatware: Coming to terms with our fleshy selves

ACKNOWLEDGEMENTS
ENDNOTES
BIBLIOGRAPHY
PICTURE CREDITS
INDEX
 
Review Quotes
Science
“A winding romp through advances in cell biology [that] pushes readers to ponder the boundaries of life. . . . Because of the immense power of emerging biotechnologies, those of us who are intimately involved with these advances must make a concerted effort to equip both policy-makers and the public with the knowledge and tools needed to navigate this evolving landscape. Ambitious and expansive, How to Grow a Human could be one piece of this effort—Ball’s look at the state of human-facing cutting-edge bio­science is a thought-provoking read.”
Nature
"Should probably come with a warning: you might never look at the life sciences in quite the same way again. . . . Faced with technologies that cheat death and circumvent reproduction, Ball forces us to reassess what being human actually means. . . . This is a deeply engaging crash course. Ball’s description of cellular organelles and their functions, in particular, is an impressive feat. And his sense of wonder at biological processes is palpable: passages on the intricacies of cell plasticity had me (with my doctorate in molecular biology) exclaiming, 'That is incredible!'"
Chemistry World
"Ball skilfully guides us through the last hundred years or so of our love affair of tinkering with the cell. With a writer with as many awards under his belt as Ball, you’re in safe hands as he unpacks the science of the cell, while injecting plenty of color and lively anecdotes to keep things interesting. By the end of the book, you’ll have learned that mothers giving birth to a male child can end up with cells with Y chromosomes that live on for years, and that rat stem cells can make a mouse a new gall bladder, despite rats not even having a gall bladder."
Lancet
"Ball weaves a compelling story of bodily creation. . . . Highly readable and impeccably informed by research, How to Grow a Human revels in scientific possibility and confronts the social and ethical implications, while intelligently acknowledging what is as yet unknown."
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